Whole-genome sequencing as an alternative to cytogenetic analysis in myeloid cancers

Matthew Walther, Eric Duncavage

A study at Washington University (St. Louis, MO) found that whole-genome sequencing provided rapid an accurate genomic profiling in patients with AML or MDS. WGS also provided a greater diagnostic yield than conventional cytogenetic analysis and more efficient risk stratification on the basis of standard risk categories.