Trends in severe anal intraepithelial neoplasia in the United States, 1996-2019
Dr. Cameron Haas
Anal intraepithelial neoplasia grade III (AIN3) is a precursor to squamous cell carcinoma of the anus, for which rates are nearly 20-fold higher in people with HIV (PWH) than in de general population in the United States. Analysis of registry data in 11 states and Puerto Rico and Washington DC found that rates of AIN3 diagnoses have increased since 1996, particularly among people living with HIV, possibly influenced by increased screening. A prior AIDS diagnosis was strongly associated with risk of AIN3 diagnosis.
