Trends in breast cancer death rates from ductal carcinoma in situ versus invasive cancer in the United States

Breast ductal carcinoma in situ (DCIS), considered a non-obligate precursor to invasive breast cancer, has been widely studied; however, trends in death rates from DCIS remain undocumented. Analysis of 8 SEER registries found that death rate from DCIS increased by 2,43% annually (95% CI 1.34-3.54) from 2000-2015, and then plateaued. This trend was in stark contrast with an average of 1.61% annual decrease in death rate for invasive breast cancer (95% CI -1.95 to -1.27). The authors conclude that these results highlight important implications for understanding the natural history and management of these malignancies.