T cells persist for years in melanoma patients after durable responses to immunotherapy

Researchers at The Geisel School of Medicine at Dartmouth (Lebanon, NH) probed memory CD8⁺ T-cell responses across tissues in a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy. Single-cell RNA sequencing revealed three subsets of resident memory T cells shared between tumors and distant vitiligo-affected skin.Clonotypes from tumors were found in patients skin and blood up to 9 years treatment.