Systematic review and meta-analysis of MRI-based versus PSA-based prostate cancer screening

Prof. Shahrokh Shariat

Prostate MRI is increasingly used in screening for prostate cancer (PCa). In a systematic review and meta-analysis of 80,114 screened men from 12 studies, MRI-based screening was found to be associated with a reduced number of unnecessary prostate biopsies and detection of clinically insignificant prostate cancer, while maintaining the detection of clinically significant prostate cancer compared with prostate-specific antigen-only strategies. The authors conclude that the findings of this meta-analysis support the integration of MRI in prostate cancer screening to improve the balance of patient harms and benefits.