Systematic review and meta-analysis of de novo colorectal cancer after kidney transplantation

Kidney transplant (KT) patients have higher risk of developing de novo colorectal cancer (CRC) compared to the general population. Systematic review and meta-analysis of published studies investigated clinicopathologic characteristics and outcomes of de novo CRC among KT recipients. Among 1855 KT patients developing CRC, the mean time from transplantation to CRC diagnosis was 8.7 years. De novo CRC was most commonly located in the ascending colon (43.6%). Advanced CRC at diagnosis was seen in 37.1%. Although 68.8% underwent curative intent treatment, pooled 5-year survival rate was 31.8%. There was wide heterogeneity between studies.