Systematic review and meta-analysis of clinicopathological features of hepatoid and non-hematoid adenocarcinoma of the stomach

Hepatoid adenocarcinoma of the stomach (HAS) is a rare malignant gastric tumor with a worse prognosis than non-hepatoid adenocarcinoma of the stomach (non-HAS). Researchers of Sichuan University (Chengdu, China) carried out a systematic review and meta-analysis of nine retrospective studies to compare HAS and non-HAS patients. There were no significant differences between HAS and non-HAS patients in age, sex, tumor size, T3 or T4 stage, and N2 or N3 stage. The HAS group exhibited higher rates of lymph node metastasis (OR 1.93; p=0.007), liver metastasis (3.45; p<0.001), and vascular invasion (3.45; pxtagstartz0.001). The HAS group compared with the non-HAS group had lower rates of