Systematic review and meta-analysis of breast cancer and incidence of type 2 diabetes mellitus

Breast cancer and its treatments may increase the risk of type 2 diabetes (T2D). A systematic review and meta-analysis of published studies found that compared with women without breast cancer, risk of T2D was increased by 23%. In analyses limited to breast cancer patients, the risk of T2D was higher for those who received tamoxifen compared with those who did not receive tamoxifen (Effect Estimate = 1.28; 95% CI 1.18-1.38). Due to few studies, analyses investigating T2D risk after treatments with aromatase inhibitors or chemotherapy were inconclusive.