Survival impact of intensive versus minimalist follow-up after surgery for endometrial cancer

In the absence of clear evidence from randomized trials, the intensity of follow-up regimens after surgical treatment for endometrial cancer is highly variable in clinical practice. The multicenter randomized TOTEM study in Italy and France compared intensive versus minimalist follow-up after surgery for endometrial cancer. The 5-year overall survival was 90.6% with intensive follow-up versus 91.9% with minimalist follow-up. The authors conclude that there is no reason to systematically add vaginal cytology, laboratory, or imaging investigations to the follow-up of scheduled clinical visits and chest, abdomen, and pelvis CT in the first two years, even in high-risk patients.