Skeletal adverse events in childhood cancer survivors

An Adult Life after Childhood Cancer in Scandinavia (ALiCCS) cohort study found that survivors of cancer diagnosed before 20 years of age, compared with age- and sex-matched comparison subjects, had increased risk of hospitalization for skeletal adverse events (RR 1.35; 95% CI 1.29-1.42). The survivors had increased risk of osteonecrosis (RR 25.9; 95% CI 15.0-44.5), osteoporosis (4.53; 3.28-6.27), fractures (1.27; 1.20-1.34), osteochondropathies (1.57; 1.28-1.92), and osteoarthrosis (1.48; 1.28-1.72). The risk of hospitalization for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lieftime pattern was different for each type of event.