Short-term changes in body mass index and waist circumference and HCC risk in South Korea
A longitudinal study in South Korea included 6,789,472 individuals who underwent health examinations in 2009 and in 2011. During median 6.4 years of follow-up 9,952 participants were diagnosed with hepatocellular carcinoma. Compared with individuals with normal BMI (< 25 kg/m2) in 2009 and in 2011, the risk of HCC was increased in individuals with normal BMI in 2009 and overweight in 2011 (aHR 1.10; 95% CI 1.01-1.20) and in individuals with overweight in 2009 and 2011 (1.28; 1.23-1.34), and compared to individuals with normal waist circumference (< 90 cm in men and < 85 cm in women) in 2009 and in 2011, the risk of HCC was increased in individuals with normal waist circumference in 2009 and high waist circumference in 2011 (1.19; 1.11-1.27) and in individuals with high waist circumference in 2009 and high waist circumference in 2011 (1.33; 1.26-1.40).