SEER database analysis of incidence and survival outcomes of gastrointestinal stromal tumors in adult patients

Updated data on trends and survival outcomes of gastrointestinal stromal tumors (GISTs) are lacking. Analysis of the SEER-22 and SEER-7 registries investigated data from patients aged 20 years and older with GISTs diagnosed between January 1, 2000, and December 31, 2019. In this cohort study of 23,001 patients, agge-adjusted incidence rates for common digestive GISTs increased between 2% and 7% in the study period, mostly for early-stage tumors. Survival disparities among racial and ethnic groups were found for some organ sites. The authors conclude that these findings suggest that the incidence of GISTs in major organ sites has increased in the last two decades among several population groups.