Risk of second brain tumor after radiotherapy for pituitary adenoma or craniopharyngioma

Radiotherapy is a valuable treatment in the management algorithm of pituitary adenomas and craniopharyngiomas. However, the risk of second brain tumor following radiotherapy is a major concern. A retrospective multicenter cohort study found that adult patients undergoing radiotherapy for pituitary adenoma or craniopharyngioma were at increased risk of second brain tumors, although this risk was considerably lower than previously reported in studies using general population controls with no imaging surveillance