Review of bio-magnetic nanomedicine for targeted drug delivery in breast cancer

The conventional chemotherapy and ligand-based nanocarriers approaches for breast cancer are facing challenges due to treatment resistance, tumor heterogeneity, and off-target toxicity. In this context, bio-magnetic nanomedicine has emerged as a revolutionary approach, utilizing magnetic nanoparticles for precise drug delivery that goes beyond passive enhanced permeability and retention processes. A review by researchers at Liaoning Cancer Hospital & Institute (Shenyang, China) investigated the relationship of green synthesis, functional design, and translational issues in the development of bio-magnetic nanocarriers for breast cancer treatment. The review highlights the nano-bio-magnetic interaction, imaging-guided theranostics, and biosafety issues related to iron homeostasis, ferroptosis, and the relative importance of green-synthesized approaches. Translational and clinical challenges such as magnetic field penetration, large scale manufacturing and emerging trends are discussed. The authors conclude that the review highlights biomagnetic nanomedicine as a precision navigation platform to advance breast cancer therapy.