Retrospective study of outcomes of cutaneous squamous cell carcinoma among patients with versus without transplant-associated immunosuppression

Cutaneous squamous cell carcinoma (cSCC) may occur with multiple primary tumors, metastasize, and cause death both in immunocompetent and immunosuppressed patients. In a Norwegian cohort study of cSCC patients comprising 46,784 non-organ transplant recipients (non-OTRs) and 1208 OTRs with registry data spanning more that 5 decades, OTRs had significantly elevated rates of second tumor, metastasis, and death from cSCC. In both groups, most deaths were from causes other than cSCC.