Retrospective study of clinicopathological features and survival outcomes after R0 resection for lung adenosquamous carcinoma

Retrospective analysis of the Japanese Joint Committee of Lung Cancer Registry database aimed to clarify clinicopathologic features and prognostic factors of lung adenosquamous carcinoma (ASC) afte RO resection compared with resected lung adenocarcinoma (AC) and resected lung squamous cell carcinoma (SC). The ASC group had worse 5-year recurrence-free survival rate (44.4%) than the AC group (73.1%; p<0.001) and the SC group 55.9%; p<0.001). The 5-year overall survival rate in the ASC group was (57,5%) compared with 83.9% (p<0.001) in the AC group (83,9%; p<0,001) and 62.3% in the SC group (p=0.086). In multivariate analysis, prognostic factors that affected OS for ASC were male sex, p-stage II-III, and postoperative complications. Sensitizing EGFR mutation was detected in 21.5% of screened ASC patients, but it did not affect survival outcomes. Both multivariate and IPTW-adjusted analyses did not show positive impact of adjuvant chemotherapy on survival in ASC. The authors conclude that lung ASC was more aggressive than both AC and SC.