Retrospective cohort study of survival determinants and sociodemographic disparities in early-onset non-small cell lung cancer

Patients with early-onset non-small cell lung cancer (diagnosed before age 50 years) represent a distinct and relatively understudied population. A cohort study using the SEER database included 18,595 patients with early-onset NSCLC. In this study, overall survival differed significantly based on stage at diagnosis and modifiable factors, including time from diagnosis to treatment, household income, and residential setting. The authors conclude that these findings suggest the need for earlier detection and targeted efforts to reduce socioeconomic disparities among adults with early-onset NSCLC.