Retrospective cohort study of circulating tumor DNA and tissue testing for pancreatobiliary tumors
Dr. Hani Babiker
The prognosis of advanced pancreatico biliary tumors is poor. Next-generation sequencing (NGS) of tissue samples is utilized to identify actionable alterations, but there are occasional limitations due to inadequate tissue acquisition. In a multicenter retrospective cohort study with 790 patients, ctDNA testing significantly correlated with tissue NGS in finding actionable alterations for patients with PDAC an cholangiocarcinoma. Serial ctDNA testing found markers associated with higher odds of progressive disease. The authors conclude that ctDNA testing can be used when tissue specimens are insufficient for analysis.
