Randomized trial of a psychological intervention for caregivers of patients with primary malignant brain tumors

Caregivers of patients with primary malignant brain tumors (PMBT) experience significant psychological distress. A randomized controlled trial at Massachusetts General Hospital (Boston) evaluated the psychological intervention NeuroCARE for these caregivers. Caregivers with Generalized Anxiety Disorder-7 score ≥ 5 within 6 months of the patient’s diagnosis were randomized to NeuroCARE (six telehealth sessions with a behavioral health specialist; n=60) or usual care (n=60). Primary outcome was HADS –Anxiety Subscale score at 11 weeks. The median score was significantly lower in the NeuroCARE group than in the usual care group (8.87 versus 10.69; p=0.008). NeuroCARE caregivers also reported significantly lower depression symptoms (HADS depression subscale median 6.08 versis 7.7; p=0.004) and better self-efficacy (Lewis Scale median 128.81 versus 111.17; p<0.001) and coping (Measure of Current Status median 32.25 versus 25.65; p<0.001) at 11 weeks. Study groups did not differ significantly in 11-week quality of life, caregiver burden, or PTSD symptoms. In longitudinal analysis, intervention effects on depression symptoms, self-efficacy, and coping were sustained. The authors conclude that the NeuroCARE intervention led to improved anxiety and depression symptoms, self-efficacy, and coping among PMBT caregivers.