Prospective study of the association of healthy lifestyle with risk of liver cancer

Prospective evidence on the association of a healthy lifestyle with the risk of liver cancer is limited. The China Kadoorie Biobank cohort consists of 492,640 adults who were followed for a median of 10.1 years. Healthy lifestyle was defined as no smoking, no use of alcohol, median or higher levels of physical activity, healthy diet, and waist-to-hip ratio <0.90 for men and <0.85 for women. During the follow-up 2529 liver cancer events were observed. Participants with 4 or 5 healthy lifestyle factors had a 43% reduced risk of liver cancer compared with those with 0 or 1 healthy lifestyle factors (HR 0.57; 95% CI 0.47-0.68). The authors conclude that adhering to a healthy lifestyle was associated with a considerable absolute reduction of risk of liver cancer.