Prospective study of risk factors for COVID-19-related hospitalization and death among patients with cancer

Retrospective case series haved identified having cancer and receiving treatment for cancer as risk factors for inferior COVID-19 outcomes. The prospective National Cancer Institute COVID-19 in Cancer Patients Study (NCCAPS) investigated risk factors for COVID-19-related hospitalization and death among patients with cancer. In this cohort study of 1572 adults with cancer and a positive SARA-CoV-2 test result, the cumulative incidence of COVID-19-specific death in the first 90 days was highest in patients with lymphoma, intermediate in patients with acute leukemia and lung cancer, and lowest in patients with solid tumors and other hematologic cancers. In multivariable analysis, receipt of chemotherapy and baseline history of stroke, atrial fibrillation, or pulmonary embolism were associated with a higher risk of hospitalization, and vaccination prior to SARS-CoV-2 infection was associated with a lower risk of hospitalization.