Prospective cohort study of incidentally detected splenomegaly and risk of hematologic cancer

Splenomegaly is ofter detected incidentally, but it is unknown at which spleen length or volume risk of hematologic cancer or liver disease is substantially increased. A prospective cohort study using data from 2 independent general population cohorts from Denmark and the UK evaluated risks of hematologic cancers according to spleen length and volume in individuals with incidentally detected splenomegaly. In this cohort study including 47,066 individuals, absolute 5-year risk of any hematologic cancer was moderately increased for spleen lenghts of 130 to 139 mm or spleen volumes of 400 to 499 mL, and markedly increased for spleen lengths 0f 140 mm or greater or spleen volumes of 500 mL or greater.