Prospective associations of different combinations of aerobic and muscle-strengthening activity with all-cause, cardiovascular, and cancer mortality

Studies examining the associations of different combinations of intensity-specific aerobic and muscle-strengthening activity (MSA) with all-cause and cause-specific mortality are scarce, and the few available estimated are disparate. A nationwide prospective cohort study using data for the US National Health Interview Survey estimated associations of different combinations of moderate aerobic physical activity (MPA), vigorous aerobic physical activity (VPA), and MSA with all-cause, cardiovascular (CVD), and cancer mortality. In this cohort study of 500,705 adults with a median follow-up of 10.0 years (5.6 million person-years), balanced amounts of MPA, VPA, and MSA combined were associated with a lower risk of mortality. These risk reductions may be greater with aerobic physical activity at higher vigorous and moderate intensities than current recommendations for all-cause and cancer mortality, respectively.