Prognostic value of club cell secretory protein serum concentration after surgical resection of localized non-small cell lung cancer

No specifice follow-up strategy has shown to improve overall survival (OS) after surgical resection of non-small cell lung cancer (NSCLC). Club cell secretory protein (CCSP) is produced by bronchiolar club cells and shows promise as a survival biomarker as its concentration depends on degree of lung inflammation. A post-hoc analysis of the IFCT-0302 trial evaluated the prognostic impact of postoperative serum CCSP concentration on OS and disease-free survival (DFS) after resection of stage I to IIIA NSCLC. The analysis included 946 patients (77% male, age 63.3 ± 9.3 years) who were divided into quartiles according to CCSP concentration. In multivariable analysis, patients in quartile IV (CCSP ≥ 13.73 ng/m) compared with quartile I (CCSP < 4.72 ng/ml) had greater risk of death HR 1.30; p=0.05) and greater risk of recurrence or death (HR 1.32; p=0.025). The authors conclude that this analysis revealed that postopreative CCSP serum concentration was associated with OS and DFS after resection of localized NSCLC.