Pooled analysis of studies of association of poor oral health and survival of head and neck cancer patients

Poor oral health has been identified as a prognostic factor potentially affecting the survival of patient with head and neck squamous cell carcinoma (HNSCC). However, evidence to date supporting this association is based on single-cohort studies with small to modest sample size. A pooled analysis of 2449 HNSCC patients from 4 studies included data on periodontal disease, tooth brushing frequency, mouthwash use, numbers of natural teeth, and dental visits over the 10 years prior to diagnosis. The analysis found that remaining natural teeth and frequent dental visits were associated with better overall survival. The inverse association with natural teeth was most pronounced among patients with hypopharyngeal and/or laryngeal, and not otherwise specified HNSCC. The association with dental visits was most pronounced among patients with oropharyngeal HNSCC. Patient-reported gingival bleeding, tooth brushing, and use of mouthwash were not associated with overall survival.