Pooled analysis of prognostic value of baseline EORTC QLQ-C30 scores for overall survival across 46 clinical trials covering 17 cancer types

A pooled data analysis in 2009 found three EORTC QLQ-C30 scales to be prognostic for survival: physical functioning, pain, and appetite loss. A validation study comprising a broader cancer population has now been published. The study included 16,210 patients from 46 trials covering 17 cancer types. The stratified model, adjusting for socio-demographic and clinical variables, confirmed that baseline better physical functioning (HR 0.94; 95% CI 0.93-0.96), lower pain (1.02; 1.01-1.03), and appetite loss (1.04; 1.03-1.05) were significantly associated with survival. Additionally, global health status/QoL, dyspnea, emotional, and cognitive functioning were prognostic for survival. The authors conclude that baseline scores 7 EORTC QLQ-C30 scales predict survival in cancer patients.