Pan-cancer analysis of postdiagnosis exercise and mortality

The impact of postdiagnosis exercise on cause-specific mortality in cancer survivors and wheter this differs on the basis of cancer site is unclear. Analysis of 11,480 patients with cancer enrolled in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial found that exercise consistent with guidelines was associated with a significant reduction of the hazard of all-cause mortality and the hazards of cancer mortality and mortality from other causes. The inverse relationship between exercise and cause-specific mortality varied by dose. For individual cancer sites, the mortality benefit of exercise was driven primarily by a reduction in death from other causes; the impact on the cancer mortality differed as a function of cancer site.