Outcomes and molecular features of brain metastasis in gastroesophageal adenocarcinoma

A retrospective cohort study at Memorial Sloan Kettering Cancer Center found that a notable proportion of patients with brain metastasis from gastroesophageal adenocarcinoma achieve survival 1 and 2 years after diagnosis of brain metastasis, a more favorable prognosis than previously reported. Good performance status and treatment with combination of surgery and radiotherapy were associated with the best outcomes. ERBB2 positivity and amplification as well as PTPRT alterations were enriched in brain metastasis tissue compared with primary tumors.