Multinational study of spatial distribution of the proteome in the human body and in cancers

A detailed, spatially resolved quantitative map of the human proteome is essential for a deeper understanding of human biology and disease. A multinational study of a comprehensive human proteomic landscape was published in Nature. The authors profiled more than 13,000 proteins across 2,856 samples using data-independent acquisition mass spectrometry. The dataset spans 58 major tissue types, 251 specificic tissue subtypes, and 25 distinct carcinomas. This resource enables the depiction of spatially resolved proteome trajectories acrosse tissue types and physiological states, including fetal, tumor, adjacent nontumor and healthy adult tissue, thereby providing insight into both developmental processes and oncogenic progression. Furthermore, quantitative proteomics comparisons across diverse tissue types and states facilitate the indication of organ-specific toxicity, the identification of repurposable anticancer drug candidates, and the prioritization of therapeutic targets for cancers. The authors conclude that this study establishes a quantitative resource for navigation the proteome in the human body and in common cancers.