Multinational retrospective cohort study of the IMPACT tool to risk stratify patients with incidental meningioma

Incidental meningiomas are common. There is a need for a validated clinical tool to stratify patients into early intervention, serial monitoring, or safe discharge from outpatient care. A multinational retrospective cohort study was carried out to externally validate the Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and Magnetic Resonance Imaging Tests (IMPACT) tool. The study included 1248 patients from 33 centers in 15 countries. The IMPACT tool accurately predicted the risk of incidental meningioma progression: 1 in 2 patients with IMPACT high-risk disease progressed, compared with 1 in 4 with medium-risk and 1 in 25 with low-risk disease. Accordingly, these groups can be stratified into early intervention, serial monitoring, or safe discharge. The authors conclude that the IMPACT tool is an externally validated tool that may be used for the management of patients with incidental meningioma.