Multinational retrospective cohort study of salvage focal therapy versus radical prostatectomy for localized radiorecurrent prostate cancer

Patients with recurrent prostate cancer after previous radiotherapy typically have poor survival. Thos with recurrences confined to the prostate might be suitable for salvage focal therapy (sFT) or salvage radical prostatectomy (sRP). A multinational cohort study compared cancer control and perioperative complications with sFT versus sRP among patient with localized recurrent prostate cancer. In this study with a mean matched cohort size of 554 patients, 10-year cancer-specific survival and overall survival were not meaningfully different between sFT and sRP. The adjusted odds of any and major complications were approximately 24 and 9 times higher, respectively, following sRP compared to sFT. The authors conclude that sFT and sRP are both effective for treating localized radiorecurrent prostate cancer, though sFT confers fewer perioperative complications.