Multinational randomized trial of simple versus radical hysterectomy in women with low-risk cervical cancer

Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises question regarding the need for radical hysterectomy in these patients. Data from large, randomized trials comparing outcomes of radical and simple hysterectomy are lacking. The multinational randomized noninferiority CX.5 SHAPE trial (n=700) compared simple hysterectomy versus radical hysterectomy in patients with low-risk cervical cancer. Simple hysterectomy was not inferior to radical hysterectomy with respect to the 3-year incidence of pelvic recurrence (2.52% versus 2.17%), and was associated with a lower risk of urinary incontinence or retention (quick take video summary).