Multinational randomized trial of microultrasonography-guided versus MRI-guided biopsy for prostate cancer diagnosis

High-resolution microultrasonography-guided biopsy is an alternative to MRI fusion-guided biopsy for prostate cancer diagnosis. The randomized OPTIMUM trial, at 20 centers in 8 countries, compared high-resolution microultrasonography-guided biopsy versus MRI fusion-guided biopsy. In this trial, that included 678 participant, microultrasonography-guided biopsy was noninferior to MRI fusion-guided biopsy for detection of Gleason Grade Group 2 or higher prostate cancer (difference, 3.52%; 95% CI -3.95% to + 10.92%; noninferiority p<0.001). The authors conclude that microultrasonography-guided biopsy may provide an alternative to MRI for image-guided prostate biopsy (visual abstract).