Multicenter retrospective study of association between dietary quality and chemotherapy-induced peripheral neuropathy in colon cancer

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting chemotoxicity caused by oxaliplatin. A secondary analysis of the Focus on Reducing Dose-Limiting Toxicities in Colon Cancer with Resistance Exercise (FORCE) study evaluated the relationship between baseline dietary quality (based on AHEI-2010 analysis of food-frequency questionnaires) and the development of moderate and/or severe CIPN in colon cancer patients receiving oxaliplatin chemotherapy. Higher dietary quality was associated with a significantly decreased risk of moderate-severe CIPN. Consumption of red and processed meat and sugar-sweetened beverages was associated with an increased risk of severe CIPN, whereas consumption of vegetables was associated with reduced risk of severe CIPN. The authors conclude that among patients with colon cancer receiving oxaliplatin chemotherapy, higher baseline dietary quality was associated with a reduced risk of moderate-severe CIPN.