Multicenter randomized trial of survival impact of prechirurgical peritumoral lidocaine infiltration in early breast cancer

There is preclinical and clinical evidence of surgical dissemination leading to metastases. Surgery-induced acute hypoxia can activate prometastatic pathways through voltage-gated sodium channels, which can be blocked by local anesthetics. A multicenter randomized trial in India evaluated peritumoral infiltration of lidocaine before surgery in early breast cancer. Compared with the control group, the lidocaine group had significantly better disease-free survival (HR 0.74; p=0.017) and overall survival (HR 0.71; p=0.019).