Multicenter prospective study of long-term locoregional outcomes of breast cancer in young women

Women diagnosed with breast cancer at a young age are felt to have a higher risk of locoregional recurrence (LRR) regardless of type of local therapy. The contemporary multicenter prospective Young Women’s Breast Cancer Study enrolled 1135 women diagnosed with stage I to III breast cancer between 2006 and 2016. The risk of isolated LRR was 5.6% at a median follow-up of 10.1 years, and no significant differences were seen based on type of surgery or molecular subtype. The authors conclude that concerns for long-term risk of LRR should not impact surgical decision-making among young women, irrespective of molecular subtype.