Multicenter cross-sectional study of frequency and clinical associations of common mental disorders in adults with high-grade glioma

A cross-sectional study at 13 centers in Germany found that among patients with high-grade glioma, the proportion of patients who had mental disorders was 31% (95% CI 28-35). Psychiatric comorbidity was associated with younger age (younger than 50 years versus 65 year or older OR 1.9; p=0.04), stable disease versus complete remission (1.7; p=0.04), lower income (<EUR 1500 per months versus higher 1.7; p=0.04), living alone (1.6; p=0.05), self-reported fatigue (1.6; p=0.03), and self-reported impaired cognitive functioning (2.3; pxtagstartz0.01). There was no evidence for indepentdent effects of gender, histology, affected lobe, time since diagnosis, or employment status. The authors conclude that approximately one third of adult patients with high-grade glioma suffered from a clinically relevant common mental disorder, without notable disparity between men and women.