Incidence of metastatic prostate cancer before and after the USPSTF recommendations against routine prostate cancer screening

The US Preventive Services Task Force has recommended against routine PSA-based prostate cancer (PCa) screening, initially for men older than 75 years in 2008, and then for all men in 2012. A cohort study of 836,282 patients with PCa from the SEER database found that before the change in USPSTF recommendations, the incidence rate of metastatic prostate cancer (mPCa) was stable among men aged 45 to 74 years and decreasing among men older than 75 years. After the change in USPSTF recommendations, the incidence rate of mPCa increased in men of all ages. The authors conclude that in the US the incidence of mPCa is increasing, which might be temporally associated with the change in USPSTF recommendations.