Generalizability of polygenic risk scores for breast cancer among women with European, African, or Latinx ancestries

A cohort study found that polygenic risk score models for breast cancer derived from women with European ancestry generalized well for women with European, Latinx, and African ancestries across different clinical setting, although the effect sizes for women with African ancestry were smaller, likely because of differences in risk allele frequencies and linkage disequilibrium patterns. These results highlight the need to improve representation of diverse population groups, particularly women with African ancestry, in genomic research cohorts.