Family history of plasma cell disorders and overall survival in MGUS, multiple myeloma, and systemic AL amyloidosis

The association between familial plasma cell disorders and prognosis in patients with MGUS, multiple myeloma, and systemic light chain amyloidosis has not been well described. A retrospective study at the Mayo Clinic (Rochester, MN) found that having a family history of plasma cell disorders was associated with longer overall survival among patients with MGUS (HR 0.52; p<0.001), multiple myeloma (HR 0,68; p<0.001), or systemic AL amyloidosis (HR 0.60; p=0.003).