Epidemiology of cancer-associated venous thromboembolism in patients in the Veterans Affairs health care system, 2006-2021

Identifying changes in epidemiologic patterns of the incidence and risk of cancer-associated thrombosis (CAT), particularly with evolving cancer-directed therapy, is essential for risk stratification. In a cohort study of 434,203 patients with solid tumor and hematologic neoplasms in the Department of Veterans Affairs health care system, a high incidence of CAT with yearly trends ranging stably from 4.2% to 4.7% over the 16-year study period was observed. Cancer type and stage and systemic treatment were significantly associated with CAT, and patients of different races and ethnicities demonstrated varying degrees of risk of CAT.