Effect of focal versus extended irreversible electroporation for localized low- or intermediate-risk prostate cancer on early oncological control

Irreversible electroporation (IRE) is a tumor ablation technique that uses nonthermal, high-voltage, low-energy electrical pulses between electrodes to create permanent pores in cell membranes, triggering cell death. Focal IRE treats only the area of the tumor, aiming achieving oncological control while reducing treatment-related functional detriment. A randomized clinical trial at five European centers investigated effects of focal versus extended IRE for localized low- or intermediate-risk prostate cancer on early oncological control. The study found that focal and extended IRE achieved similar oncological outcomes after six months. The authors conclude that, since some patients with intermediate-risk prostate cancer are still candidates for active surveillance, focal IRE may be a promising option for those patients with a high risk of cancer progression (visual abstract).