Development of cancer among patients with pediatric-onset inflammatory bowel disease

The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing. The hallmarks of IBD are progressive intestinal injury and systemic inflammation, which could lead to complications such as cancer. Meta-analysis of 5 population-based studies showed a greater than 2-fold increased rate of cancer among patients with pediatric-onset IBD compared with the general pediatric populations, primarily owing to an increased rate of gastrointestinal cancers.