Daily insulin dose and cancer risk among patients with type 1 diabetes
Dr. Yuanjie Mao
Previous studies among persons with type 1 diabetes (T1D) found a higher incidence of certain cancers in this population compared with the general population. Analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC) found that among T1D patients higher age and female sex were associated with cancer risk, while exercising habit and hihg-density lipoprotein cholesterol were inversely associated. After correction for age and sex, daily insulin dose was associated with cancer incidence. The incidence was 2.11, 2.87, and 2.91 per 1000 person-years in the low-, medium-, and high-dose groups, respectively.
