Cumulative burden of late, major, surgical interventions in survivors of childhood cancer

Analysis of the Childhood Cancer Survivor Study cohort found that survivors had a significant burden of late, major surgical interventions, with a 35-year mean cumulative count of 206.7 per 100 survivors, compared with 128.9 per 100 nearest-age siblings (adjusted RR 1.8; 95% CI 1.7-1.9). Survivors diagnosed in the 1990s had an increased likelihood of late surgery compared with those diagnosed in the 1970s (aRR 1.4; 95% CI 1.3-1.5). Highest cumulative burdens of late, major surgical interventions were seen in survivors of Hodgkin lymphoma, Ewing sarcoma, and osteosarcoma. Locoregional surgery or radiotherapy cancer treatment was associated with undergoing late surgical intervention in the same body region or organ system.