Cohortstudie van associatie tussen overgewicht en risico van tweede primaire maligniteiten onder overlevers van eerste maligniteiten

Little is known about the causes of second primary cancers among individuals with a history of cancer. Descriptive studies have suggested that lifestyle factors, including excess body weight, may be important. A cohort study using data of 26,894 adult cancer survivors in 21 US states from the Cancer Prevention Study II Nutrition cohort investigated whether excess body weight is associated with a second primary malignant neoplasm. Among these survivors of nonmetastatic cancer, 42.8% had overweight and 17.2% had obesity at their first primary cancer diagnosis. Excess body weight was associated with increased risk of any second primary cancer, especially obesity-related second primary cancer. The authors conclude that these results emphasize the importance of recommending healthy weight and heightening awareness of second cancers among physicians of cancer survivors.