Cohort study of cancer incidence and trends in US adults with HIV

In a cohort study of 847.107 adult people with HIV in the USA, the incidence of non-Hodgkin lymphoma, Kaposi sarcoma, and Hodgkin lymphoma, as well as lung and liver cancer, continually decreased from 2001 to 2019. However, there has been less clear progress in reducing the incidence of HPV-driven cancer (eg , cervix and anus), cancers that are more common in the general population (eg, breast, prostate, colon), and a concerning increase in vulvar cancer. The authors conclude that improvements in health care for individuals with HIV have continued to contribute to declines in the incidence of several cancer that are associated with immunosuppression, but the relative risk for most other cancers has not changed substantially.