Cohort study of association of oral bacterial and fungal microbiome with subsequent risk of pancreatic cancer

The association of prediagnostic oral bacterial and fungal microbiome with subsequent development of pancreatic cancer is not clear. Pooled analysis of two prospective cohorts, including more than 122,000 individuals, found that 3 oral bacterial periodontal pathogens, an additional 20 bacteria, and 4 fungi together conferred a more than 3-fold increase in the risk of pancreatic cancer. The authors conclude that the oral fungal and bacterial microbiotas may serve as a readily accessible, noninvasive biomarkers for subsequent pancreatic cancer risk to identify individuals at high risk.