Clinicopathologic analysis of pineal parenchymal tumors of intermediate dirfferentiation

Pineal parenchymal tumors of intermediate differentiation (PPTIDs), which were recognized in the 2007 World Health Organizaton classification account for less than 1% of all central nervous system tumors A retrospective study by the Kyushu Neuro-Oncology Study Group in Japan investigated characteristics, treatment, and outcomes of PPTIDs. Median age at diagnosis was 49 years, and the male/female ratio was 1/1.2. Surgery was attempted in all patients, and gross total resection was achieved in 46% of patients. Adjuvant radiotherapy and chemotherapy were used in 82% and 46%, respectively. Five-year PFS and OS rates were 64.9% and 70.4%, respectively. female sex and gross total resection were independent prognostic factors for PFS. Initial and second recurrences were mostly leptomeningeal.