Clinical outcomes and prognostic factors in triple-negative invasive lobular carcinoma of the breast

Triple-negative invasive lobular carcinoma (TN-ILC) of the breast is a rare disease, and the clinical outcomes and prognostic factors are not well-defined. Analysis of the National Cancer Database found that women with TN-ILC of the breast were older at diagnosis but had similar overall survival compared to women with triple-negative invasive ductal carcinoma (TN-IDC) of the breast after adjusting for tumor and demographic characteristics. Administration of chemotherapy was associated with improved overall survival in TN-ILC, but women with TN-ILC were less likely to achieve complete response to neoadjuvant therapy compared to women with TN-IDC. Among women with TN-ILC receiving neoadjuvant chemotherapy, the 5-year OS was 77.3% in women with pCR compared to 39.8% in women without response.